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Data accessibility

Finalized datasets from our studies and publications will be made available freely at the CRCNS.org, Mendeley Data, or equivalent websites to the extent feasible and allowable by institutional regulations. The sharing of unpublished information may be subject to confidentiality issues relating to our collaborations with other scientists in academic or corporate laboratories, and will need to be discussed with the appropriate institutions before any request is granted, wholly or in part. Biosamples generated from laboratory research and/or obtained from research participants may be available for sharing with other research groups via request after execution of appropriate Materials Transfer and Data Use Agreements.

Regarding code and design sharing, after academic journal publication, GitHub or similar online publication forums for sharing of code, design files and/or plans for our research data will be used. GitHub or another git-related site is preferable as this will allow others in the community to improve upon our work and to commit their changes to an online repository for others to see, share and modify.

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Featured publications

The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans

Bueno-Junior LS, Ruckstuhl MS, Lim MM, Watson BO. Proc Natl Acad Sci USA. 2023 May 2;120(18):e2213438120. doi: 10.1073/pnas.2213438120. Epub 2023 Apr 24. PMID: 37094161.

Comprehensive review on risk factors for Parkinson's Disease and evidence-based screening and neuroprotective approaches to prevent progression of disease.

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Baseline characteristics of the North American prodromal Synucleinopathy cohort

Elliott JE, Lim MM, Keil AT, Postuma RB, Pelletier A, Gagnon JF, St. Louis EK, Forsberg LK, Fields JA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS. Ann Clin Transl Neurol. 2023 Apr;10(4):520-535. doi: 10.1002/acn3.51738. Epub 2023 Feb 8. PMID: 36751940; PMCID: PMC10109527.

Foundational publication describing the baseline characteristics of the NAPS cohort - the world's largest registry of patients with REM sleep behavior disorder (n=361), collected across 10 sites in North America.

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Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.

Milman NEP, Tinsley CE, Raju RM, Lim MM. Neurobiology of Sleep and Circadian Rhythms. 2023; 14: 100085. doi: 10.1016/j.nbscr.2022.100085. PMID: 36567958; PMCID: PMC9768382.

Scoping review of rodent studies examining the function of sleep in early development.

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Screening and Targeting Risk Factors for Prodromal Synucleinopathy: A Prescriptive Multi-modal Framework

Neilson LE, Quinn JF, Lim MM. Aging and Disease. 2023 Aug 1;14(4):1243-1263. doi: 10.14336/AD.2022.1024. PMID: 37307836; PMCID: PMC10389816.

Comprehensive review on risk factors for Parkinson’s Disease and evidence-based screening and neuroprotective approaches to prevent progression of disease

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Dietary Supplementation With Branched Chain Amino Acids to Improve Sleep in Veterans With Traumatic Brain Injury: A Randomized Double-Blind Placebo-Controlled Pilot and Feasibility Trial

Elliott JE, Keil AT, Mithani S, Gill JM, O'Neil ME, Cohen AS, Lim MM. Front Syst Neurosci. 2022 May 4;16:854874. doi: 10.3389/fnsys.2022.854874. PMID: 35602971; PMCID: PMC9114805.

First-in-human small pilot randomized clinical trial for branched chain amino acid dietary supplementation to improve sleep in Veterans with TBI - translated from our previous studies in mice.

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Photosensitivity Is Associated with Chronic Pain following Traumatic Brain Injury

Balba NM, McBride AA, Callahan ML, Mist SD, Jones KD, Butler MP, Lim MM, Heinricher MM. J Neurotrauma. 2022 Sep;39(17-18):1183-1194. doi: 10.1089/neu.2022.0019. Epub 2022 May 17. PMID: 35373595; PMCID: PMC9422792.

Photosensitivity is strongly associated with chronic pain scores among nearly 400 Veterans with TBI.

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Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial

Elliott JE, McBride AA, Balba NM, Thomas SV, Pattinson CL, Morasco BJ, Wilkerson A, Gill JM, Lim MM. PLoS One. 2022 Apr 14;17(4):e0262955. doi: 10.1371/journal.pone.0262955. PMID: 35421086; PMCID: PMC9009710.

Clinical trial examining the feasibility of using light therapy to improve sleep and blood-based biomarkers in Veterans with TBI.

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Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles

Jones CE, Chau AQ, Olson RJ, Moore C, Wickham PT, Puranik N, Guizzetti M, Cao H, Meshul CK, Lim MM. Curr Res Neurobiol. 2021;2:100020. doi: 10.1016/j.crneur.2021.100020. Epub 2021 Jul 10. PMID: 35505895; PMCID: PMC9060254.

We had previously shown that early life sleep disruption caused persistently altered affiliative social behavior in normally highly social, monogamous prairie voles. This publication provides a potential explanation for those findings by highlighting changes in glutamate and dendritic spines within prefrontal cortex of the affected prairie voles.

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Different Methods for Traumatic Brain Injury Diagnosis Influence Presence and Symptoms of Post-Concussive Syndrome in United States Veterans

Elliott JE, Balba NM, McBride AA, Callahan ML, Street KT, Butler MP, Heinricher MM, Lim MM. J Neurotrauma. 2021 Nov 15;38(22):3126-3136. doi: 10.1089/neu.2021.0031. Epub 2021 Sep 8. PMID: 34382417; PMCID: PMC8917885.

This publication highlights the importance of rigorous diagnostic criteria for TBI in clinical research studies and sets forth the rationale for the diagnostic methods for TBI used in SHARP studies.

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The Bidirectional Link Between Sleep Disturbances and Traumatic Brain Injury Symptoms: A Role for Glymphatic Dysfunction?

Piantino JA, Iliff JJ, Lim MM. Biol Psychiatry. 2022 Mar 1;91(5):478-487. doi: 10.1016/j.biopsych.2021.06.025. Epub 2021 Jul 14. PMID: 34481662; PMCID: PMC8758801.

High profile review proposing the hypothesis for how glymphatic dysfunction underlies the bidirectional relationship between TBI and sleep disturbances.

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Posttraumatic stress disorder increases the odds of REM sleep behavior disorder and other parasomnias in Veterans with and without comorbid traumatic brain injury.

Elliott JE, Opel RA, Pleshakov D, Rachakonda T, Chau AQ, Weymann KB, Lim MM. Sleep. 2020 Mar 12;43(3):zsz237. doi: 10.1093/sleep/zsz237. PMID: 31587047; PMCID: PMC7315766.

Prospective consecutive study showing significantly elevated diagnostic rates of REM sleep behavior disorder among Veterans with TBI and PTSD, which has implications for linking TBI/PTSD to neurodegenerative disease.

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Early-life sleep disruption increases parvalbumin in primary somatosensory cortex and impairs social bonding in prairie voles.

Jones CE, Opel RA, Kaiser ME, Chau AQ, Quintana JR, Nipper MA, Finn DA, Hammock EAD, Lim MM. Sci Adv. 2019 Jan 30;5(1):eaav5188. doi: 10.1126/sciadv.aav5188. PMID: 30729165; PMCID: PMC6353622.

Foundational publication establishing a causal role for sleep in shaping neural circuits during development and social behavior using the prairie vole.

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Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury.

Lim MM, Elkind J, Xiong G, Galante R, Zhu J, Zhang L, Lian J, Rodin J, Kuzma NN, Pack AI, Cohen AS. Sci Transl Med. 2013 Dec 11;5(215):215ra173. doi: 10.1126/scitranslmed.3007092. PMID: 24337480; PMCID: PMC3951738.

First study showing dietary supplementation with branched chain amino acids in a mouse model of TBI improves sleep via modulation of orexin neurons in the hypothalamus.

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Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Science. 2009 Nov 13;326(5955):1005-7. doi: 10.1126/science.1180962. Epub 2009 Sep 24. PMID: 19779148; PMCID: PMC2789838.

Landmark study first demonstrating a causal role for sleep in driving amyloid-beta pathology in a mouse model of Alzheimer's disease.

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Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene.

Lim MM, Wang Z, Olazábal DE, Ren X, Terwilliger EF, Young LJ. Nature. 2004 Jun 17;429(6993):754-7. doi: 10.1038/nature02539. PMID: 15201909.

Surprising study showing that a complex social behavior can be flipped from promiscuous to monogamous tendencies in the vole by manipulating a single gene within a single brain region.

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