Finalized datasets from our studies and publications will be made available freely at the CRCNS.org, Mendeley Data, or equivalent websites to the extent feasible and allowable by institutional regulations. The sharing of unpublished information may be subject to confidentiality issues relating to our collaborations with other scientists in academic or corporate laboratories, and will need to be discussed with the appropriate institutions before any request is granted, wholly or in part. Biosamples generated from laboratory research and/or obtained from research participants may be available for sharing with other research groups via request after execution of appropriate Materials Transfer and Data Use Agreements.
Regarding code and design sharing, after academic journal publication, GitHub or similar online publication forums for sharing of code, design files and/or plans for our research data will be used. GitHub or another git-related site is preferable as this will allow others in the community to improve upon our work and to commit their changes to an online repository for others to see, share and modify.
Bueno-Junior LS, Ruckstuhl MS, Lim MM, Watson BO. Proc Natl Acad Sci USA. 2023 May 2;120(18):e2213438120. doi: 10.1073/pnas.2213438120. Epub 2023 Apr 24. PMID: 37094161.
Comprehensive review on risk factors for Parkinson's Disease and evidence-based screening and neuroprotective approaches to prevent progression of disease.
Elliott JE, Lim MM, Keil AT, Postuma RB, Pelletier A, Gagnon JF, St. Louis EK, Forsberg LK, Fields JA, Huddleston DE, Bliwise DL, Avidan AY, Howell MJ, Schenck CH, McLeland J, Criswell SR, Videnovic A, During EH, Miglis MG, Shprecher DR, Lee-Iannotti JK, Boeve BF, Ju YS. Ann Clin Transl Neurol. 2023 Apr;10(4):520-535. doi: 10.1002/acn3.51738. Epub 2023 Feb 8. PMID: 36751940; PMCID: PMC10109527.
Foundational publication describing the baseline characteristics of the NAPS cohort - the world's largest registry of patients with REM sleep behavior disorder (n=361), collected across 10 sites in North America.
Milman NEP, Tinsley CE, Raju RM, Lim MM. Neurobiology of Sleep and Circadian Rhythms. 2023; 14: 100085. doi: 10.1016/j.nbscr.2022.100085. PMID: 36567958; PMCID: PMC9768382.
Scoping review of rodent studies examining the function of sleep in early development.
Neilson LE, Quinn JF, Lim MM. Aging and Disease. 2023 Aug 1;14(4):1243-1263. doi: 10.14336/AD.2022.1024. PMID: 37307836; PMCID: PMC10389816.
Comprehensive review on risk factors for Parkinson’s Disease and evidence-based screening and neuroprotective approaches to prevent progression of disease
Elliott JE, Keil AT, Mithani S, Gill JM, O'Neil ME, Cohen AS, Lim MM. Front Syst Neurosci. 2022 May 4;16:854874. doi: 10.3389/fnsys.2022.854874. PMID: 35602971; PMCID: PMC9114805.
First-in-human small pilot randomized clinical trial for branched chain amino acid dietary supplementation to improve sleep in Veterans with TBI - translated from our previous studies in mice.
Balba NM, McBride AA, Callahan ML, Mist SD, Jones KD, Butler MP, Lim MM, Heinricher MM. J Neurotrauma. 2022 Sep;39(17-18):1183-1194. doi: 10.1089/neu.2022.0019. Epub 2022 May 17. PMID: 35373595; PMCID: PMC9422792.
Photosensitivity is strongly associated with chronic pain scores among nearly 400 Veterans with TBI.
Elliott JE, McBride AA, Balba NM, Thomas SV, Pattinson CL, Morasco BJ, Wilkerson A, Gill JM, Lim MM. PLoS One. 2022 Apr 14;17(4):e0262955. doi: 10.1371/journal.pone.0262955. PMID: 35421086; PMCID: PMC9009710.
Clinical trial examining the feasibility of using light therapy to improve sleep and blood-based biomarkers in Veterans with TBI.
Jones CE, Chau AQ, Olson RJ, Moore C, Wickham PT, Puranik N, Guizzetti M, Cao H, Meshul CK, Lim MM. Curr Res Neurobiol. 2021;2:100020. doi: 10.1016/j.crneur.2021.100020. Epub 2021 Jul 10. PMID: 35505895; PMCID: PMC9060254.
We had previously shown that early life sleep disruption caused persistently altered affiliative social behavior in normally highly social, monogamous prairie voles. This publication provides a potential explanation for those findings by highlighting changes in glutamate and dendritic spines within prefrontal cortex of the affected prairie voles.
Elliott JE, Balba NM, McBride AA, Callahan ML, Street KT, Butler MP, Heinricher MM, Lim MM. J Neurotrauma. 2021 Nov 15;38(22):3126-3136. doi: 10.1089/neu.2021.0031. Epub 2021 Sep 8. PMID: 34382417; PMCID: PMC8917885.
This publication highlights the importance of rigorous diagnostic criteria for TBI in clinical research studies and sets forth the rationale for the diagnostic methods for TBI used in SHARP studies.
Piantino JA, Iliff JJ, Lim MM. Biol Psychiatry. 2022 Mar 1;91(5):478-487. doi: 10.1016/j.biopsych.2021.06.025. Epub 2021 Jul 14. PMID: 34481662; PMCID: PMC8758801.
High profile review proposing the hypothesis for how glymphatic dysfunction underlies the bidirectional relationship between TBI and sleep disturbances.
Elliott JE, Opel RA, Pleshakov D, Rachakonda T, Chau AQ, Weymann KB, Lim MM. Sleep. 2020 Mar 12;43(3):zsz237. doi: 10.1093/sleep/zsz237. PMID: 31587047; PMCID: PMC7315766.
Prospective consecutive study showing significantly elevated diagnostic rates of REM sleep behavior disorder among Veterans with TBI and PTSD, which has implications for linking TBI/PTSD to neurodegenerative disease.
Jones CE, Opel RA, Kaiser ME, Chau AQ, Quintana JR, Nipper MA, Finn DA, Hammock EAD, Lim MM. Sci Adv. 2019 Jan 30;5(1):eaav5188. doi: 10.1126/sciadv.aav5188. PMID: 30729165; PMCID: PMC6353622.
Foundational publication establishing a causal role for sleep in shaping neural circuits during development and social behavior using the prairie vole.
Lim MM, Elkind J, Xiong G, Galante R, Zhu J, Zhang L, Lian J, Rodin J, Kuzma NN, Pack AI, Cohen AS. Sci Transl Med. 2013 Dec 11;5(215):215ra173. doi: 10.1126/scitranslmed.3007092. PMID: 24337480; PMCID: PMC3951738.
First study showing dietary supplementation with branched chain amino acids in a mouse model of TBI improves sleep via modulation of orexin neurons in the hypothalamus.
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM. Science. 2009 Nov 13;326(5955):1005-7. doi: 10.1126/science.1180962. Epub 2009 Sep 24. PMID: 19779148; PMCID: PMC2789838.
Landmark study first demonstrating a causal role for sleep in driving amyloid-beta pathology in a mouse model of Alzheimer's disease.
Lim MM, Wang Z, Olazábal DE, Ren X, Terwilliger EF, Young LJ. Nature. 2004 Jun 17;429(6993):754-7. doi: 10.1038/nature02539. PMID: 15201909.
Surprising study showing that a complex social behavior can be flipped from promiscuous to monogamous tendencies in the vole by manipulating a single gene within a single brain region.